Fig 1From: Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functionsViability of mouse liver slices upon treatment. Slices obtained from livers of WT and FXRKO mice (denoted as WT-PCLS and FXRKO-PCLS, respectively) were incubated for 24 h with 40 μM of cyclosporin A (CsA) or vehicle control (DMSO). ATP content (nmol/mg of protein) in slices treated with CsA was compared to control slices (DMSO). Each point is the mean ± SD of 5 independent experiments. None of the measured parameters was significantly affectedBack to article page