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Fig. 3 | BMC Genomics

Fig. 3

From: Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions

Fig. 3

Identification of significantly affected genes. To identify genes significantly affected by CsA in WT-PCLS and FXRKO-PCLS, analysis of variance (ANOVA) was performed and corrected for FDR by the Benjamini test. Venn diagrams of significantly upregulated (FDR ≤0.05) and downregulated (FDR ≤ 0.05) genes in WT-PCLS and FXRKO-PCLS are presented in (a and b), respectively. The top 25 significantly upregulated and downregulated genes are presented as heat maps in (c and d), respectively. Each heat map shows fold change (treatment vs. control) calculated in individual experiments based on normalized gene expression values of DNA microarrays. WT-PCLS or WT indicates slices obtained from wild type (WT) mice. FXRKO-PCLS or KO indicates slices obtained form Fxr-knockout (FXRKO) mice. Red color indicates upregulation and green shows downregulation

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BMC Genomics

ISSN: 1471-2164

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