Fig 5

Functional and hierarchical clustering analysis of genes identified in GO processes related to “ECM” uniquely regulated in WT-PCLS. Genes identified in the significant GO-processes (FDR ≤ 0.005) related to “ECM” in WT-PCLS are presented as a network and a heat map. The network consists of 3 functional clusters shown as circles and denoted as: metalloproteinases (1), collagens (2), and development/morphogenesis (3). Connected nodes within the functional clusters indicate known gene-gene interactions and genes for which gene-gene interactions are unknown are presented as unconnected nodes. Thicker lines represent stronger associations between genes. Inter-cluster edges are represented by dashed lines. The heat map is the result of hierarchical clustering of log2, median centered, gene expression values in slices obtained from individual mice. Red and green indicate expression higher and lower, respectively, than the average expression of all samples within the heat map. WT stands for control (DMSO-treated) slices obtained from WT mice. WTCSA stands for CsA treated slices obtained from WT mice. KO stands for control (DMSO) slices obtained from FXRKO mice. KOCSA stands for CsA treated slices obtained from FXRKO mice