Table 1 Pathway analysis of the commonly affected genes by CsA in WT-PCLS and FXRKO-PCLS
Functional category | Pathways | FDR | In Data | Total | |
|---|---|---|---|---|---|
Upregulation | ER stress | Endoplasmic reticulum stress response pathway | 2.0E-08 | 16 | 55 |
ER stress | Role of PKR in stress-induced apoptosis | 3.2E-05 | 12 | 53 | |
ER stress | CFTR folding and maturation (normal and CF) | 3.4E-05 | 8 | 21 | |
ER stress | APRIL and BAFF signaling | 2.0E-03 | 8 | 39 | |
ER stress | ATM/ATR regulation of G1/S checkpoint | 3.3E-03 | 7 | 32 | |
ER stress | Regulation of degradation of deltaF508-CFTR in CF | 1.7E-05 | 11 | 39 | |
ER stress | wtCFTR traffic/ER-to-Golgi (normal) | 5.0E-04 | 6 | 15 | |
ER stress | DeltaF508-CFTR traffic/ER-to-Golgi in CF | 5.0E-04 | 6 | 15 | |
ER stress | RAB1A regulation pathway | 1.8E-03 | 5 | 12 | |
ER stress | DeltaF508-CFTR traffic/Sorting endosome formation in CF | 1.8E-03 | 7 | 28 | |
ER stress | Regulation of degradation of wtCFTR | 1.9E-03 | 6 | 20 | |
ER stress | Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway | 4.3E-03 | 6 | 24 | |
ER stress | Clathrin-coated vesicle cycle | 4.6E-03 | 10 | 71 | |
Metabolic diseases | Role of free fatty acids in obesity and type 2 diabetes | 2.6E-04 | 10 | 45 | |
Metabolic diseases | Role of ER stress in obesity and type 2 diabetes | 9.9E-04 | 10 | 54 | |
Inflammation | IL-17 signaling pathways | 1.8E-03 | 10 | 60 | |
Inflammation | CD40 signaling | 3.0E-03 | 10 | 65 | |
Inflammation | Role of PKR in stress-induced antiviral cell response | 4.4E-03 | 9 | 57 | |
Downregulation | Coagulation | Thromboxane A2 pathway signaling | 4.7E-04 | 13 | 49 |
Coagulation | Lectin induced complement pathway | 4.7E-04 | 13 | 49 | |
Coagulation | HTR2A-induced activation of cPLA2 | 1.1E-03 | 11 | 43 | |
Coagulation | Blood coagulation | 1.8E-03 | 10 | 39 | |
Coagulation | Classical complement pathway | 3.4E-03 | 11 | 52 | |
Coagulation | MIF - the neuroendocrine-macrophage connector | 4.2E-03 | 10 | 46 | |
Coagulation | Alternative complement pathway | 4.6E-03 | 9 | 39 | |
Regulation of energy metabolism | CREB pathway | 2.1E-03 | 11 | 49 | |
Regulation of energy metabolism | Regulation of lipid metabolism by niacin and isoprenaline | 3.7E-03 | 10 | 45 | |
Regulation of energy metabolism | Bile acids regulation of glucose and lipid metabolism via FXR | 3.7E-03 | 9 | 37 | |
Regulation of energy metabolism | PPAR pathway | 3.7E-03 | 12 | 63 |