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Table 3 GO analysis of genes uniquely regulated in WT-PCLS or FXRKO-PCLS

From: Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions

  General process GO process (WT-PCLS) FDR Direction of change
WT-PCLS ECM GO:0031012 ~ extracellular matrix 9.4E-10 Downregulation
ECM GO:0005578 ~ proteinaceous extracellular matrix 2.0E-09 Downregulation
ECM GO:0044421 ~ extracellular region part 1.5E-06 Downregulation
ECM GO:0005576 ~ extracellular region 2.0E-04 Downregulation
FXRKO-PCLS Inflammation GO:0005125 ~ cytokine activity 6.1E-05 Upregulation
Inflammation GO:0005615 ~ extracellular space 4.6E-03 Upregulation
Inflammation GO:0006935 ~ chemotaxis 9.8E-03 Upregulation
Inflammation GO:0042330 ~ taxis 9.8E-03 Upregulation
Mitochondrial functions GO:0005739 ~ mitochondrion 2.0E-11 Downregulation
Mitochondrial functions GO:0048037 ~ cofactor binding 1.5E-03 Downregulation
Mitochondrial functions GO:0044429 ~ mitochondrial part 2.9E-03 Downregulation
  1. GO analysis of the significant genes (FDR ≤ 0.05) uniquely regulated by CsA in WT-PCLS or FXRKO-PCLS. GO analysis was performed in DAVID and GO process was considered as significant if FDR ≤ 0.005. In addition, the GO processes were grouped according to their general function and these groups are depicted in column denoted as “General function”. The last column informs whether a GO process was up- or down-regulated (“Direction of change”)