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Table 1 Demographics, clinical phenotypes and haematological values for de novo and drug-naïve PD patients and healthy controls

From: Blood transcriptomics of drug-naïve sporadic Parkinson’s disease patients

Diagnostic group Parkinson’s disease Controls
Discovery set Validation set Discovery set Validation set
Number 40 12 20 12
Gender (Male/Female), number 22/18 6/6 10/10 5/7
Age, yr, mean (SD; range) 68.83 (6.94; 51–78) 68.82 (5.22; 59–76) 60.30 (5.69; 53–69) 68.00 (1.5; 65–71)
Age at symptoms onset, yr, mean (SD; range) 67.65 (6.80; 50–76) 67.63 (5.05; 58–74) NA NA
Symptom duration, yr, mean (SD; range) 1.14 (0.66; 0.5–3) 1.49 (0.85; 0.5–3) NA NA
Clinical phenotype at enrollment:
Unilateral symptoms, number (%) 24 (60) 10 (83.3) NA NA
Bilateral symptoms, number (%) 16 (40) 2 (16.7) NA NA
Tremor, number (%) 7 (17.5) 3 (25.0) NA NA
Bradykinesia/rigidity, number (%) 10 (25.0) 3 (25.0) NA NA
Mixed, number (%) 23 (57.5) 6 (50.0) NA NA
Hoehn and Yahr stage, mean (SD; range) 1.45 (0.55; 1–2) 1.50 (0.71; 1–3) NA NA
UPDRS motor score, mean (SD; range) 14.72 (8.15; 3–29) 13.82 (7.22; 1–24) NA NA
MMSE score, mean (SD; range) 29.77 (0.48; 29–30) 29.73 (0.90; 27–30) NA NA
123I-FP-CIT SPECT abnormality:
Type 1, number (%) 21 (55.3) 6 NA NA
Type 2, number (%) 17 (44.7) 5 NA NA
Not executed, number 2 1 NA NA
Haematological values (mean, SD):
White blood cells [10A3/^L] 6.19 (1.58) 4.97 (1.47) 5.76 (1.24) 5.78 (1.09)
Neutrophils (%) 61.67 (8.18) 59.35 (14.64) 57.52 (6.18) 57.74 (5.85)
Lymphocytes (%) 27.85 (7.49) 28.92 (2.72) 31.31 (6.52) 30.63 (6.21)
Monocytes (%) 7.40 (1.73) 8.50 (2.72) 7.38 (1.74) 8.73 (2.42)
Eosinophils (%) 2.62 (1.52) 2.60 (1.89) 3.17 (1.81) 2.42 (1.24)
Basophils (%) 0.49 (0.16) 0.67 (0.36) 0.63 (0.26) 0.63 (0.20)
Red blood cells [10A6/^L] 4.59 (0.49) 4.44 (0.55) 4.79 (0.44) 4.74 (0.44)
Hemoglobin [g/dL] 14.40 (1.23) 14.28 (1.49)) 14.14 (0.88) 14.85 (0.52)
MCV fL] 91.44 (4.61) 94.05 (3.03) 88.56 (4.54) 94.13 (5.37)
MCH [pg] 31.53 (2.42) 32.35 (1.47) 30.16 (1.77) 32.08 (2.10)
MCHC [g/dl] 34.46 (1.22) 34.37 (0.59) 34.05 (0.76) 34.05 (0.51)
Platelet count [10A3/^L] 226.71 (66.72) 176.33 (14.87) 221.60 (43.62) 226.92 (78.05)
  1. NA not applicable, Yr year, UPDRS Unified Parkinson’s Disease Rating Scale, MMSE Mini-Mental State Examination