Table 1 Demographics, clinical phenotypes and haematological values for de novo and drug-naïve PD patients and healthy controls
From: Blood transcriptomics of drug-naïve sporadic Parkinson’s disease patients
Diagnostic group | Parkinson’s disease | Controls | ||
|---|---|---|---|---|
Discovery set | Validation set | Discovery set | Validation set | |
Number | 40 | 12 | 20 | 12 |
Gender (Male/Female), number | 22/18 | 6/6 | 10/10 | 5/7 |
Age, yr, mean (SD; range) | 68.83 (6.94; 51–78) | 68.82 (5.22; 59–76) | 60.30 (5.69; 53–69) | 68.00 (1.5; 65–71) |
Age at symptoms onset, yr, mean (SD; range) | 67.65 (6.80; 50–76) | 67.63 (5.05; 58–74) | NA | NA |
Symptom duration, yr, mean (SD; range) | 1.14 (0.66; 0.5–3) | 1.49 (0.85; 0.5–3) | NA | NA |
Clinical phenotype at enrollment: | ||||
Unilateral symptoms, number (%) | 24 (60) | 10 (83.3) | NA | NA |
Bilateral symptoms, number (%) | 16 (40) | 2 (16.7) | NA | NA |
Tremor, number (%) | 7 (17.5) | 3 (25.0) | NA | NA |
Bradykinesia/rigidity, number (%) | 10 (25.0) | 3 (25.0) | NA | NA |
Mixed, number (%) | 23 (57.5) | 6 (50.0) | NA | NA |
Hoehn and Yahr stage, mean (SD; range) | 1.45 (0.55; 1–2) | 1.50 (0.71; 1–3) | NA | NA |
UPDRS motor score, mean (SD; range) | 14.72 (8.15; 3–29) | 13.82 (7.22; 1–24) | NA | NA |
MMSE score, mean (SD; range) | 29.77 (0.48; 29–30) | 29.73 (0.90; 27–30) | NA | NA |
123I-FP-CIT SPECT abnormality: | ||||
Type 1, number (%) | 21 (55.3) | 6 | NA | NA |
Type 2, number (%) | 17 (44.7) | 5 | NA | NA |
Not executed, number | 2 | 1 | NA | NA |
Haematological values (mean, SD): | ||||
White blood cells [10A3/^L] | 6.19 (1.58) | 4.97 (1.47) | 5.76 (1.24) | 5.78 (1.09) |
Neutrophils (%) | 61.67 (8.18) | 59.35 (14.64) | 57.52 (6.18) | 57.74 (5.85) |
Lymphocytes (%) | 27.85 (7.49) | 28.92 (2.72) | 31.31 (6.52) | 30.63 (6.21) |
Monocytes (%) | 7.40 (1.73) | 8.50 (2.72) | 7.38 (1.74) | 8.73 (2.42) |
Eosinophils (%) | 2.62 (1.52) | 2.60 (1.89) | 3.17 (1.81) | 2.42 (1.24) |
Basophils (%) | 0.49 (0.16) | 0.67 (0.36) | 0.63 (0.26) | 0.63 (0.20) |
Red blood cells [10A6/^L] | 4.59 (0.49) | 4.44 (0.55) | 4.79 (0.44) | 4.74 (0.44) |
Hemoglobin [g/dL] | 14.40 (1.23) | 14.28 (1.49)) | 14.14 (0.88) | 14.85 (0.52) |
MCV fL] | 91.44 (4.61) | 94.05 (3.03) | 88.56 (4.54) | 94.13 (5.37) |
MCH [pg] | 31.53 (2.42) | 32.35 (1.47) | 30.16 (1.77) | 32.08 (2.10) |
MCHC [g/dl] | 34.46 (1.22) | 34.37 (0.59) | 34.05 (0.76) | 34.05 (0.51) |
Platelet count [10A3/^L] | 226.71 (66.72) | 176.33 (14.87) | 221.60 (43.62) | 226.92 (78.05) |