Fig. 1

Global expression analysis in aging mouse liver. a Percent of globally expressed transcript subspecies expressed across both young and old livers from our unique annotation set of 47,510 annotated transcripts. b Table represents the number of genomic bases covered by at least one unique read in either all old livers, all young livers, or both old and young livers. Total mouse genome size reference used at time of analysis using GRCm38 build is 2,293,712,140 bases for a haploid genome. c Differential transcript expression plotted log₂FoldChange(Old/Young) versus the mean gene dispersion value. Red points represent all 1264 significant differentially expressed transcripts with FDR <0.1. Old (n = 3), Young (n = 3). d Heatmap representation of the top 100 differentially expressed transcripts by P-value, generated using unsupervised hierarchical clustering