Patterns of gene expression and DNA methylation in human fetal and adult liver

BMC Genomics

Table 2 Percentage of CpG sites by location category and methylation level

Gene Expression	Tissue	Location on Gene	Number of CpGs	Hypomethylation (%)	Intermediate Methylation (%)	Hypermethylation (%)
Fetal Overexpressed	Fetal	TSS/Ex1	1640	76	10	14
	Fetal	UTR/GB	2312	31	11	58
	Adult	TSS/Ex1	1640	71	11	18
	Adult	UTR/GB	2312	27	15	58
Adult Overexpressed	Fetal	TSS/Ex1	912	47	16	37
	Fetal	UTR/GB	957	24	16	61
	Adult	TSS/Ex1	912	56	24	20
	Adult	UTR/GB	957	24	21	55
Similarly Expressed	Fetal	TSS/Ex1	2464	43	34	23
	Fetal	UTR/GB	4983	31	37	32
	Adult	TSS/Ex1	2464	16	60	23
	Adult	UTR/GB	4983	12	57	30

CpGs were selected based on their relationship to genes whose expression differed significantly between fetal and adult liver (q < 0.05; fold-difference >5), or their relationship to genes that were similarly expressed in the two groups (fold-difference ≤1.1). Based on criteria described in the text, CpGs were then categorized as localized to within 200 or 1,500 base pairs of the transcription start site or the first exon (TSS/Ex1), or within the 5’UTR, 3’UTR or gene body, and as showing hypo-, intermediate or hypermethylation

ISSN: 1471-2164