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Table 2 Percentage of CpG sites by location category and methylation level

From: Patterns of gene expression and DNA methylation in human fetal and adult liver

Gene Expression Tissue Location on Gene Number of CpGs Hypomethylation (%) Intermediate Methylation (%) Hypermethylation (%)
Fetal Overexpressed Fetal TSS/Ex1 1640 76 10 14
UTR/GB 2312 31 11 58
Adult TSS/Ex1 1640 71 11 18
UTR/GB 2312 27 15 58
Adult Overexpressed Fetal TSS/Ex1 912 47 16 37
UTR/GB 957 24 16 61
Adult TSS/Ex1 912 56 24 20
UTR/GB 957 24 21 55
Similarly Expressed Fetal TSS/Ex1 2464 43 34 23
UTR/GB 4983 31 37 32
Adult TSS/Ex1 2464 16 60 23
UTR/GB 4983 12 57 30
  1. CpGs were selected based on their relationship to genes whose expression differed significantly between fetal and adult liver (q < 0.05; fold-difference >5), or their relationship to genes that were similarly expressed in the two groups (fold-difference ≤1.1). Based on criteria described in the text, CpGs were then categorized as localized to within 200 or 1,500 base pairs of the transcription start site or the first exon (TSS/Ex1), or within the 5’UTR, 3’UTR or gene body, and as showing hypo-, intermediate or hypermethylation