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Table 3 Prediction Probability of DNA Methylation Change to Gene Expression Change

From: Patterns of gene expression and DNA methylation in human fetal and adult liver

    Gene expression induced in adult
Fetal Hypermethylation Location Number of CpGs >2-Fold >5-Fold
 Fetal-to-Adult Decrease >0.2 TSS/Ex1 3,510 20 % 7 %
UTR/GB 8,807 12 % 2 %
 Fetal-to-Adult Decrease >0.5 TSS/Ex1 391 33 % 11 %
UTR/GB 1,350 14 % 2 %
    Gene Expression Induced in Fetus
Adult Hypermethylation Location Number of CpGs >2-Fold >5-Fold
 Fetal-to-Adult Increase >0.2 TSS/Ex1 22,587 7 % 2 %
UTR/GB 54,769 5 % 2 %
 Fetal-to-Adult Increase >0.5 TSS/Ex1 25,706 7 % 2 %
UTR/GB 62,226 5 % 2 %
  1. CpGs were categorized based on fetal-to-adult differences in methylation status and their location within genes (TSS/Ex1 versus UTR/GB). Their predictive value was assigned based on the fetal:adult difference in expression of the genes to which the respective CpGs were assigned