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Table 3 Prediction Probability of DNA Methylation Change to Gene Expression Change

From: Patterns of gene expression and DNA methylation in human fetal and adult liver

   

Gene expression induced in adult

Fetal Hypermethylation

Location

Number of CpGs

>2-Fold

>5-Fold

 Fetal-to-Adult Decrease >0.2

TSS/Ex1

3,510

20 %

7 %

UTR/GB

8,807

12 %

2 %

 Fetal-to-Adult Decrease >0.5

TSS/Ex1

391

33 %

11 %

UTR/GB

1,350

14 %

2 %

   

Gene Expression Induced in Fetus

Adult Hypermethylation

Location

Number of CpGs

>2-Fold

>5-Fold

 Fetal-to-Adult Increase >0.2

TSS/Ex1

22,587

7 %

2 %

UTR/GB

54,769

5 %

2 %

 Fetal-to-Adult Increase >0.5

TSS/Ex1

25,706

7 %

2 %

UTR/GB

62,226

5 %

2 %

  1. CpGs were categorized based on fetal-to-adult differences in methylation status and their location within genes (TSS/Ex1 versus UTR/GB). Their predictive value was assigned based on the fetal:adult difference in expression of the genes to which the respective CpGs were assigned