Functional analysis of differential gene expression. a Functional classification of the genes showing a differential expression in microarray analysis and based on PseudoCAP function class assignments . The proportion of genes over-expressed in PAHM4 compared to PAO1 is indicated in green and the proportion of the genes down-regulated compared to PAO1 appears in red. Hypothetical, unclassified and unknown protein and non-coding RNA sequences were excluded from the analysis. b Adapted intermediary metabolism of PAHM4 to the bronchiectasis lung. Transcripts that were found to be significantly increased (green) or decreased (red) in PAHM4 compared to PAO1 are indicated in the pathway for central metabolism based on KEGG pathways .