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Table 4 Zebrafish and mouse predicted enhancers subjected to experimental validation

From: Functionally conserved enhancers with divergent sequences in distant vertebrates

ECR Zebrafish (Zv9 July 2010) Mouse (mm9) July 2007)
Expression Coordinates Expression Coordinates
1 Spinal cord (48) chr6:20,797,116-20,798,106 negative chr5:107,545,775–107,546,750
2 Epidermis (24,48) chr6:43,538,446–43,539,094 negative chr6:98,881,656–98,882,625
negative chr6:98,883,956–98,884,889
3 Tail bud (24), eye (48), heart (48) chr9:11,657,708–11,658,704 not tested  
4 Notochord (24,48) chr19:22,713,465–22,714,026 negative chr18:80,876,694–80,877,675
negative chr18:80,876,778–80,877,739
5 Epidermis (24,48) chr19:41,272,614–41,273,241 not tested  
6 Epidermis (24,48), Otic Vesicle (24,48), Somitic muscle (24,48) chr2:39,790,777–39,791,782 Epidermis (24,48), Notochord (24), Olfactory epithelium (24,48), Spinal cord (24), Otic Vesicle (48), Pectoral fin (48) chr1:77,387,974–77,389,004
7 Hindbrain (24,48), Olfactory epithelium (24,48) chr2:39,792,312–39,793,241 Eye (24,48), Olfactory bulb (24,48), Hindbrain (24,48) chr1:77,390,034–77,391,031
8 Somitic muscle (24,48), Olfactory epithelium (48), Hindbrain (48) chr2:39,837,096–39,838,009 negative chr1:77,503,689–77,504,676
negative chr1:77,506,344–77,507,445
9 Spinal cord (24,48) chr4:16,470,975–16,471,819 Midbrain (24), Yolk (24) chr10:87,004,979–87,005,964
Somitic Muscle (24,48), Skin under yolk (24,48), Phar. Arches (48), Pectoral fin (48) chr10:87,008,830–87,009,792
10 Somitic muscle (24,48), Olfactory epithelium (48) chr9:22,365,926–22,366,799 Somitic Muscle (24,48), Pericardium (24,48) chr14:58,234,894–58,235,874
11 Hindbrain (24), Somitic muscle (24,48), Heart (48) chr9:22,368,460–22,369,405
12 Epidermis (24,48), Otic vesicle (24,48), Yolk (24,48) chr14:41,645,428–41,646,386 Epidermis (24), Olfactory epithelium (24) chrX:130,162,955–130,163,923
13 Hindbrain (24), Olfactory epithelium (24,48), Line under eye (24,48), Spinal cord (48) chr20:21,970,078–21,970,911 Spinal cord (24) chr12:72,999,373–73,000,279
  1. Tissues in bold (in ECR 6, 7, 10, 11, 12) show consistent enhancer activity between the mouse and zebrafish syntenic enhancers at the indicated time point (24 or 48 hpf). Each construct was injected in at least 100 embryos; the proportion of fish alive and expressing in a given tissue is shown in Additional file 2: Table S1