Fig. 1

Wellington-bootstrap scores differential footprint occupancy between DNase-seq datasets. Wellington-bootstrap was applied at footprint loci in CD8+ cells to detect over-footprinted sites relative to CD19+ cells. a 53,539 loci were sorted by increasing Wellington-bootstrap score comparing CD8 vs CD19. Eight thousand seven hundred eighty loci were deemed to be DFPs. Red indicates an excess of positive strand cuts over negative strand cuts per nucleotide position, and green indicates an excess of negative strand cuts. Common footprints at the top of the heatmap share similar DNase activity as exemplified in (b) and (d) whereas footprints with increasing differential score towards the bottom of the heatmap show increasingly differential footprints (c, e, f)