Fig. 3

Significant modulated microRNA expressions between samples types in the small RNA deep-sequencing data. Normal samples (N), primary tumors (T) and LNM (M) from 3 patients (M) were analyzed. The read counts are described for each sample. The fold change (FC) is the log 2 expression ratio in CPM. We used a generalized linear model and designed our analysis so that 3 replicates were available per condition while retaining the paired information for tissue types collected from the same patient (See Methods). a: comparison between tumors and normal samples. Up-regulated microRNA in tumors are in red and down-regulated microRNAs in tumors are in green. b: comparison between LNM and tumor samples. Up-regulated microRNAs in metastases are in red and down-regulated microRNAs in metastases samples are in green