Fig. 1

P. falciparum RRMs are divided into five RRM-families. a A multiple sequence alignment of 3D structures derived from representative members of each of the RRM families (RRM1-2, 4–6) found in P. falciparum is provided. RRM_4 is found to be highly diversified from typical RRM classes (RRM_1, RRM_5, RRM_6) followed by RRM_2. b Phylogenetic reconstruction of evolutionary relationship between RRM families from P. falciparum. Phylogenetic reconstruction of RRM families using representative domains from multiple PfRRMs failed to resolve the RRM families as expected, which may be due to relative number of RRMs used to represent each class (for example, RRM 2 and 4 have one domain each). c Representative 3D homology models for each of the RRM family were constructed using 3ucg, 3u1l, 2evz, 1p27 and 3zef PDB models as a reference to PF3D7_0923900, PF3D7_0515000, PF3D7_0606500, PF3D7_0623400, and PF3D7_0405400, respectively. It can clearly be seen that RRM4 (PfPrp8) is divergent from other members both at the primary sequence and structural level