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Table 4 DEGs and their associated pathways in U. unicinctus exposed to sulfide

From: Transcriptional response to sulfide in the Echiuran Worm Urechis unicinctus by digital gene expression analysis

Pathway U. unicinctus Unigene accession number Gene annotation Differential expression multiplication log2 Ratio (TPM time/ TPM control)
6 h 24 h 48 h
Apoptosis      
Unigene6112_No.2 caspase-3 2.23 2.90 1.85
CL530.Contig1_No.2 caspase-7 2.16 1.73 1.54
Glycolysis      
CL3519. Contig1_No.2 pyruvate kinase −0.64 −1.08 −0.85
Unigene2735_No.2 phosphorylase −0.43 −1.08 −0.58
CL1308. Contig1_No.2 phosphofructokinase −0.70 −0.59 −1.08
Unigene1913_No.2 ADP-dependent glucokinase −6.77 −4.93 −6.34
CL5108.Contig1_No.2 phosphoglycerate kinase −1.68 −1.61 −1.40
MAPK      
Unigene2294_No.2 cPLA2 3.38 4.17 2.67
Unigene1096_No.2 RSK2 3.61 2.12 2.40
NF-κB      
Unigene8158_No.2 TLR4 3.09 1.24 1.30
Unigene15896_No.2 Myd88 3.06 1.95 2.27
Unigene3552_No.2 NEMO 1.45 0.94 0.61
Unigene5808_No.2 RIP1 3.68 1.44 1.59
Oxidative phosphorylation      
Unigene1548_No.2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like −1.76 −1.07 −1.48
Unigene1556_No.2 NADH-ubiquinone oxidoreductase −2.01 −2.56 −1.79
Unigene2512_No.2 NADH dehydrogenase −8.48 −8.48 −8.48
Unigene1586_No.2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9-like −1.13 −0.75 −0.87
Unigene2306_No.2 succinate dehydrogenase [ubiquinone] iron-sulfur subunit −1.24 −0.33 −0.31
Unigene1680_No.2 ubiquinol-cytochrome c reductase 1.06 0.68 0.44
Unigene1299_No.2 cytochrome c oxidase subunit I 1.00 1.21 1.43
Unigene1383_No.2 mitochondrial H+ ATPase a subunit 1.19 0.51 0.47
p53      
CL5080.Contig1_No.2 PIDD 4.68 3.07 3.26
Sulfide oxidation      
Unigene2733_No.2 sulfide-quinine oxidoreductase 0.35 0.47 1.30
Unigene4395_No.2 sulfur dioxygenase −0.83 −0.10 −0.20
Unigene1081_No.2 sulfur transferase 0.13 0.27 0.20