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Fig. 3 | BMC Genomics

Fig. 3

From: The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine

Fig. 3

The proportions of DMC1- and ATR-positive cells increase upon treatment. a Spreads from control and ATZ-treated mice were stained with anti-DMC1 (red) and anti-SYCP3 (green). In control mice, the DSBs are repaired at this stage, such that no DMC1 foci are detectable. In ATZ-treated samples (middle and low panels), several DMC1 foci are detectable at the pachytene stage. b Spreads stained with anti-ATR (green) and anti-SYCP3 (red). In control mice, the ATR signal is detected in sex bodies only, while ATR staining is detected at several chromosomes in ATZ-treated mice. c Quantitative analysis of ATR staining. The spreads were costained with ATR and SYCP3 antibodies and classified according to pattern: sex body only (shown in blue) and sex body with staining of autosomal chromosomes (shown in red)

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BMC Genomics

ISSN: 1471-2164

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