Skip to main content
Fig. 3 | BMC Genomics

Fig. 3

From: Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias

Fig. 3

553 differentially expressed genes common to FVC and DLCO by continuous analysis were evaluated by (a) canonical pathways and (b) protein-protein interactome analysis. Pathways and their associated –log P value, as determined by the Fisher Exact Test in Ingenuity Pathway Analysis, are shown as the blue bars. The ratio of the number of genes mapping to these pathways relative to the total number of genes in the pathway is plotted as orange squares. The interactome was created using NetworkAnalyst [33] and the InnateDB PPI dataset by first importing all 553 genes and then reducing the network to zero-order interactome. The nodes are colored based on their correlation of expression and lung function variables (green are negative and red are positive correlations). The sizes of nodes are proportional to their betweenness centrality values

Back to article page