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Table 1 Subject demographics and clinical characteristics of the derivation (LTRC) cohort by IIP subcategory

From: Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias

Disease groupa

Control

All IIPs

IPF

INSIP

UF

RB-ILD

P value (IIP vs control)

P value (IIP subtypes)

Number

50

167

119

17

13

11

  

Age - mean (std dev)

47.5 (16.4)

60.9 (10.2)

62.6 (8.7)

57.2 (12.2)

56.7 (16.4)

52.2 (10.9)

<0.0001*

0.0016***

Gender – % male

54

61

65

53

62

36

0.41**

0.27**

Race - % Caucasian

82

87

94

82

85

82

0.067**

0.18**

Smoker –

      

<0.0001**

0.12**

 Current

21 (42 %)

3 (3 %)

0 (0 %)

1 (6 %)

0 (0 %)

1 (9 %)

 Former

7 (14 %)

96 (55 %)

70 (59 %)

11 (65 %)

6 (46 %)

6 (55 %)

 Never

20 (40 %)

58 (35 %)

41 (34 %)

4 (24 %)

7 (54 %)

4 (36 %)

 Unknown

2 (4 %)

10 (7 %)

8 (7 %)

1 (6 %)

0 (0 %)

0 (0 %)

Pack years - mean (std dev)b

22.1 (19.5)

58.6 (103)

69.9 (115)

20.5 (23.8)

21.8 (14.1)

53.3 (30.8)

0.080*

0.37***

St George’s score - mean (std dev)

NA

48.3 (21.0)

46.6 (22.2)

50.9 (16.6)

54.5 (20.6)

37.8 (17.0)

NA

0.24***

Pre-BD FVC, %predicted - mean (std dev)

NA

63.1 (19.1)

61.3 (16.8)

69.9 (22.2)

59.7 (27.6)

85.7 (13.1)

NA

0.0005***

DLCO, %predicted - mean (std dev)

NA

48.4 (21.9)

45.9 (20.3)

58.7 (22.1)

48.7 (16.6)

77.1 (21.3)

NA

<0.0001***

  1. aIIP = idiopathic interstitial pneumonia, IPF = idiopathic pulmonary fibrosis, UIP = usual interstitial pneumonia, iNSIP = idiopathic nonspecific interstitial pneumonia, UF = uncharacterized fibrosis, RB-ILD = respiratory bronchiolitis associated interstitial lung disease. Data not reported individually for cryptogenic organizing pneumonia (COP) (n = 3) and desquamative interstitial pneumonia (DIP) (n = 4) categories
  2. bAverage for current and former smokers
  3. *Two-tailed student’s t-test
  4. **Fisher’s exact test
  5. ***One-way ANOVA