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Table 1 Subject demographics and clinical characteristics of the derivation (LTRC) cohort by IIP subcategory

From: Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias

Disease groupa Control All IIPs IPF INSIP UF RB-ILD P value (IIP vs control) P value (IIP subtypes)
Number 50 167 119 17 13 11   
Age - mean (std dev) 47.5 (16.4) 60.9 (10.2) 62.6 (8.7) 57.2 (12.2) 56.7 (16.4) 52.2 (10.9) <0.0001* 0.0016***
Gender – % male 54 61 65 53 62 36 0.41** 0.27**
Race - % Caucasian 82 87 94 82 85 82 0.067** 0.18**
Smoker –        <0.0001** 0.12**
 Current 21 (42 %) 3 (3 %) 0 (0 %) 1 (6 %) 0 (0 %) 1 (9 %)
 Former 7 (14 %) 96 (55 %) 70 (59 %) 11 (65 %) 6 (46 %) 6 (55 %)
 Never 20 (40 %) 58 (35 %) 41 (34 %) 4 (24 %) 7 (54 %) 4 (36 %)
 Unknown 2 (4 %) 10 (7 %) 8 (7 %) 1 (6 %) 0 (0 %) 0 (0 %)
Pack years - mean (std dev)b 22.1 (19.5) 58.6 (103) 69.9 (115) 20.5 (23.8) 21.8 (14.1) 53.3 (30.8) 0.080* 0.37***
St George’s score - mean (std dev) NA 48.3 (21.0) 46.6 (22.2) 50.9 (16.6) 54.5 (20.6) 37.8 (17.0) NA 0.24***
Pre-BD FVC, %predicted - mean (std dev) NA 63.1 (19.1) 61.3 (16.8) 69.9 (22.2) 59.7 (27.6) 85.7 (13.1) NA 0.0005***
DLCO, %predicted - mean (std dev) NA 48.4 (21.9) 45.9 (20.3) 58.7 (22.1) 48.7 (16.6) 77.1 (21.3) NA <0.0001***
  1. aIIP = idiopathic interstitial pneumonia, IPF = idiopathic pulmonary fibrosis, UIP = usual interstitial pneumonia, iNSIP = idiopathic nonspecific interstitial pneumonia, UF = uncharacterized fibrosis, RB-ILD = respiratory bronchiolitis associated interstitial lung disease. Data not reported individually for cryptogenic organizing pneumonia (COP) (n = 3) and desquamative interstitial pneumonia (DIP) (n = 4) categories
  2. bAverage for current and former smokers
  3. *Two-tailed student’s t-test
  4. **Fisher’s exact test
  5. ***One-way ANOVA