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Table 2 Differentially expressed genes (5 % FDR) in severe vs mild disease as characterized both by a decline in % predicted DLCO and FVC

From: Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias

Transcript ID Gene symbol p-value (Severe vs Mild DLCO) Severe/Mild Fold Change (DLCO) p-value (Severe vs Mild FVC) Severe/Mild Fold Change (FVC)
7922229 SELE 9.4E-05 2.87 2.9E-05 2.80
7921821 ADAMTS4 5.0E-05 2.22 2.8E-06 2.41
8146957 PI15 1.9E-05 2.04 1.7E-06 2.16
8043981 IL1R2 0.00035 1.86 2.5E-05 2.00
7976496 SERPINA3 9.5E-06 1.81 3.3E-05 1.76
8088560 ADAMTS9 1.4E-05 1.84 8.5E-05 1.75
8162276 NFIL3 0.00011 1.59 6.9E-06 1.63
7974851 HIF1A 6.8E-07 1.52 2.7E-07 1.57
8145122 SLC39A14 0.00012 1.51 1.9E-05 1.51
8113220 ELL2 8.2E-06 1.52 2.6E-05 1.51
8106743 VCAN 8.3E-05 1.48 0.00014 1.49
7921344 ELL2 1.6E-05 1.56 3.0E-05 1.49
7902227 GADD45A 2.6E-05 1.33 6.4E-08 1.48
8059376 SERPINE2 0.00031 1.57 0.00013 1.45
8043909 NPAS2 5.2E-05 1.56 0.00067 1.45
7897449 SPSB1 0.00011 1.36 4.3E-06 1.44
8044391 MERTK 0.00015 1.46 1.5E-05 1.43
8168749 SRPX2 1.9E-06 1.57 3.0E-05 1.43
8156043 PSAT1 0.00017 1.40 9.0E-06 1.43
8115814 SH3PXD2B 3.0E-05 1.47 3.0E-05 1.42
8106098 MAP1B 3.4E-05 1.48 0.00019 1.42
8157216 UGCG 3.8E-05 1.39 5.3E-06 1.41
8099685 LGI2 0.00032 1.45 0.00018 1.40
8007931 ITGB3 4.4E-05 1.37 5.2E-05 1.40
7986446 ALDH1A3 3.1E-05 1.49 0.0020 1.37
8105040 OSMR 0.00012 1.33 3.00E-05 1.35
8043995 IL1R1 3.4E-05 1.34 3.8E-05 1.35
7922610 ABL2 0.00034 1.39 3.8E-05 1.33
7915787 PIK3R3 2.9E-05 1.26 4.9E-05 1.33
8006123 CPD 0.00017 1.24 3.2E-05 1.27
8066939 B4GALT5 0.00026 1.25 3.2E-05 1.27
8133155 TPST1 0.00021 1.32 1.1E-05 1.25
8041168 SNORD53 0.00019 1.30 0.0018 1.25
8102482 SEC24D 1.0E-05 1.31 5.5E-05 1.24
8041149 WDR43 0.00010 1.29 0.00079 1.24
7985934 SEMA4B 0.00012 1.21 8.8E-05 1.23
8076515 ARFGAP3 0.00013 1.26 0.00035 1.21
8117128 E2F3 3.5E-06 1.27 0.00022 1.20
7966839 VSIG10 0.00021 −1.17 0.0026 −1.15
8109086 ADRB2 0.00015 −1.24 0.0013 −1.17
8035201 CPAMD8 5.5E-05 −1.30 0.0010 −1.22
8041206 LBH 0.00036 −1.33 0.0015 −1.26
7940530 C11orf9 3.2E-05 −1.24 0.0019 −1.27
8149885 ADRA1A 1.7E-05 −1.33 4.1E-05 −1.27
8082465 CCDC48 9.8E-05 −1.28 8.1E-06 −1.28
8038117 DBP 0.00019 −1.35 0.00016 −1.31
8057677 SLC40A1 0.00038 −1.41 0.0023 −1.32
7968650 C13orf36 7.1E-06 −1.38 0.00019 −1.34
8089467 ZBED2 3.5E-05 −1.45 0.00021 −1.45
8171248 KAL1 5.3E-05 −1.67 0.00077 −1.50
8155734 FAM189A2 2.0E-05 −1.56 4.0E-05 −1.54
8156569 MIR23B 0.00024 −1.71 3.0E-06 −1.66
8179967 AGER 6.22E-05 −1.81 0.0023 −1.74
8125341 AGER 7.5E-05 −1.42 0.0026 −1.77
8178771 AGER 7.1E-05 −1.67 0.0025 −1.78
8109383 GRIA1 4.9E-06 −1.86 3.4E-05 −1.81
8171427 FIGF 0.00028 −2.07 0.0011 −1.90
7933855 RTKN2 0.00020 −2.57 0.0016 −2.34