Fig. 2

Global Comparison of human and minipig tissue expression profiles. a Principal component analysis of whole transcriptome expression profiles of human (n = 3 - 9) and minipig tissues (n = 9 - 12) based on 16’032 orthologous genes. A common set of 13 tissue types is represented for each species. Tissues types were colored according to organ systems. Principal component 1 accounts for 29 %, principal component 2 for 11 %, and principal component 3 for 6 % of the variation of the data set. Related tissues cluster together between species. b Comparison of minipig whole transcriptome expression profiles to human tissue signatures. Enrichment scores are indicated by a relative color scale (by row); with red representing high similarity and white no similarity of minipig gene expression profiles to human tissue specific gene expression signatures