Fig. 4

Gene expression developmentsin minipig organs relevant for juvenile toxicity from young to adult. a Principal component analysis of whole transcriptome expression profiles of minipig tissues based on 17,254 genes. Principal component 1 accounts for 21.8 %, principal component 2 for 12.4 %, and principal component 3 for 11.3 % of total variation of the data set. b The heat map shows enrichment scores for human tissue expression signatures (red = high; white = low) in minipig tissues from young to adult. With exception of reproductive organs pairwise male and female data points for 1 week, 4 weeks, 2 months, 4 months and adult are shown