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Fig. 7 | BMC Genomics

Fig. 7

From: Complete depletion of primordial germ cells in an All-female fish leads to Sex-biased gene expression alteration and sterile All-male occurrence

Fig. 7

A schematic diagram of the hypothesized model for the leading role of germ cells on gonadal differentiation in the gynogenetic fish. The process of gonadal development is divided into three stages: before gonadal differentiation, during gonadal differentiation and mature. Before gonadal differentiation, there are PGCs and somatic precursor cells in WT gonads, whereas no PGCs in germ cell-deficient gonads. During gonadal differentiation, there are PGCs and somatic precursor cells, and early oocytes with granulosa cells and thecal cells on their surface, and estrogen-producing cells in WT gonads; however, in the germ cell-deficient gonads, there are somatic precursor cells, Sertoli cells, Leydig cells and androgen-producing cells. At mature stage, there are many mature occytes and several early occytes, granulosa cells and thecal cells surround around the occytes, and estrogen-producing cells are distributed among oocytes in WT gonads; whereas, there are many Sertoli cells arrayed into circles, Leydig cells and androgen-producing cells in the germ cell-deficient gonads

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