A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages

BMC Genomics

Table 2 List of all mutations identified in the genome of R6-SOCP^R and R6-DP1^R

Strains	Genes	Function	Mutations^a,b,c
R6-SOCP^R	spr0058	GntR-type transcription factor	G460A
R6-SOCP^R	spr0058	GntR-type transcription factor	*E154K*
	spr0093	Phosphoglycolate phosphatase	G343T
	spr0093	Phosphoglycolate phosphatase	D115Y
	spr0897	Glycerophosphoryl diester phosphodiesterase	C484A
	spr0897	Glycerophosphoryl diester phosphodiesterase	*P162T*
	spr1191	ABC protein – ATP binding domain	G1624T^d
			T1625G^d	G1629T
			V542C	L543F
	srp1443	Mur ligase homolog	T1223C
			*V408A*
	spr1584	Hypothetical protein	A1229C
	spr1584	Hypothetical protein	Y410S
	spr1777	RNA polymerase rpoB	G827C
	spr1777	RNA polymerase rpoB	R276P
	spr1923	Hypothetical protein	G690C	G691C
	spr1923	Hypothetical protein	Q230H	A231P
R6-DP1^R	spr0291	Phosphotransferase system sugar-specific EII component	C-101G
	spr1130	McrB subunit of McrBC restriction endonuclease	T985G ^d
			G986C ^d
			*C329A*
	spr1445	Dipeptidase M24 family	G918A
	spr1445	Dipeptidase M24 family	M306I
	spr1453	Major facilitator transporter	T-187G

^aFor each mutation, the change at the nucleotide level is indicated on top and the corresponding substitution at the amino acid level is indicated in italic underneath
^bMutations in bold have a confirmed role in resistance
^cFor mutations in intergenic regions, an hyphen in front of the mutated position indicates the nucleotide position upstream of the ATG
^dBoth mutated positions are part of the same codon and lead to a single amino acid substitution

ISSN: 1471-2164