Strainsa
| Allelesb,c
|
---|
spr0058 | spr0897 | spr1130 | spr1443 |
---|
R6-SOCPR
| G460A | C484A | NA | T1223C |
E154K
|
P162T
|
V408A
|
R6-SOCP-2R
| no mutation | no mutation | NA | no mutation |
R6-SOCP-3R
| no mutation | C485T | NA | T1223C |
 |
P162L
|
V408A
|
R6-SOCP-4R
| C393A | no mutation | NA | T1223C |
stop
|
V408A
|
R6-SOCP-5R
| no mutation | no mutation | NA | T1223C |
V408A
|
R6-DP1R
| NA | NA | T985Gd
| NA |
G986Cd
|
C329A
|
R6-DP1-2R
| NA | NA | T985Gd
| NA |
G986Cd
|
C329A
|
R6-DP1-3R
| NA | NA | T985Gd
| NA |
G986Cd
|
C329A
|
R6-DP1-4R
| NA | NA | no mutation | NA |
R6-DP1-5R
| NA | NA | T985Gd
| NA |
G986Cd
|
C329A
|
-
aFive different mutants had initially been obtained from the same S. pneumoniae R6 parental culture for the selection of mutants insensitive to the phages SOCP or Dp-1
-
bFor each mutation, the change at the nucleotide level is indicated on top and the corresponding substitution at the amino acid level is indicated in italic underneath
-
cNA, not applicable. These alleles were not sequenced because they should be irrelevant to the resistance phenotype of the phage
-
dBoth mutated positions are part of the same codon and lead to a single amino acid substitution