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Fig. 3 | BMC Genomics

Fig. 3

From: Integrated genomics approach to identify biologically relevant alterations in fewer samples

Fig. 3

Integrative genomic landscape of HNSCC. a Circos plot representations of genes identified by integrated genomic analysis of HNSCC cell lines. From outside to inside: karyotype, CNVs, Gene expression (FPKM), SNVs and translocations. Red colour indicates copy number gain or higher gene expression and blue colour indicates copy number loss or lower gene expression in CNV and FPKM tracks respectively. Non-synonymous mutations are indicated as blue triangles and grey circles represents non-sense mutations in SNV track. Fusion transcripts identified by transcriptome sequencing are shown as arc coloured by their chromosome of origin identified by ChimeraScan. b Heatmap representation of novel genes identified by integrated analysis of four HNSCC cell lines and their incidence in 279 HNSCC samples from TCGA study. Amplification (red) and deletions (blue) are indicated by filled box, over expression (red) and under expression (blue) are indicated by border line to the box, mis-sense (green), non-sense (black) and in-frame (brown) mutations are indicated by smaller square box

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