From: Deep sequencing of the uterine immune response to bacteria during the equine oestrous cycle
KEGG pathway | Up-regulated genes after inoculation with E. coli a | Comparison of gene counts 3Â h after inoculation with E. coli b | Genes with higher expression in oestrus at 3Â h after inoculation compared to dioestrus at 3Â h after inoculationc | Total number of genes in pathway | |||
---|---|---|---|---|---|---|---|
Oestrus | Dioestrus | Higher in oestrus | Higher in dioestrus | Up-regulated in oestrus after inoculation | Up-regulated in dioestrus after inoculation | ||
Antigen processing and presentation | 73* (32) | 52* (25) | 15 | 3 | 5 | 4 | 219 |
B cell receptor signaling pathway | 52* (12) | 35* (12) | 13 | 4 | 5 | 4 | 112 |
Chemokine signaling pathway | 107* (5) | 73* (6) | 27* | 13 | 13 | 10 | 190 |
Complement and coagulation cascades | 32 | 29* (29) | 19* | 12 | 13* | 12* | 81 |
Cytosolic DNA-sensing pathway | 34* (27) | 24* (21) | 10 | 0 | 5 | 0 | 95 |
Fc epsilon RI signaling pathway | 48* (17) | 30* (18) | 13 | 6 | 6 | 5* | 184 |
Fc gamma R-mediated phagocytosis | 64* (11) | 36* (20) | 16 | 11 | 4 | 4 | 71 |
Hematopoietic cell lineage | 54* (16) | 46* (9) | 16* | 5 | 12* | 10* | 183 |
Intestinal immune network for IgA production | 39 | 31* (39) | 5 | 0 | 3 | 3 | 227 |
Leukocyte transendothelial migration | 78* (19) | 50* (16) | 32* | 12 | 12 | 9 | 118 |
Natural killer cell mediated cytotoxicity | 100* (2) | 65* (8) | 28* | 4 | 13* | 9 | 244 |
NOD-like receptor signaling pathway | 41* (18) | 30* (14) | 11 | 5 | 8* | 7* | 129 |
RIG-I-like receptor signaling pathway | 35* (30) | 27* (19) | 10 | 6 | 6 | 5 | 114 |
T cell receptor signaling pathway | 66 | 36 | 16 | 7 | 8 | 5 | 96 |
Toll-like receptor signaling pathway | 65* (8) | 50* (7) | 19* | 6 | 11* | 9* | 78 |
Cell adhesion molecules (CAMs) | 93* (43) | 75* (15) | 29 | 13 | 11 | 8 | 320 |
Cytokine-cytokine receptor interaction | 129* (4) | 109* (2) | 52* | 14 | 36* | 32* | 273 |
Jak-STAT signaling pathway | 80* (13) | 65* (5) | 33* | 6 | 23* | 21* | 181 |
MAPK signaling pathway | 120* (9) | 78* (11) | 48* | 21 | 26* | 18* | 285 |
NF-kappa B signaling pathway | 76* (35) | 55* (23) | 18 | 5 | 8 | 7 | 241 |
TNF signaling pathway | 79* (3) | 69* (3) | 28* | 9 | 19* | 17* | 131 |