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Table 2 Enriched KEGG pathways in the category immune system (blue) and immune-related signal transduction molecules (green) after bacterial inoculation

From: Deep sequencing of the uterine immune response to bacteria during the equine oestrous cycle

KEGG pathway Up-regulated genes after inoculation with E. coli a Comparison of gene counts 3 h after inoculation with E. coli b Genes with higher expression in oestrus at 3 h after inoculation compared to dioestrus at 3 h after inoculationc Total number of genes in pathway
Oestrus Dioestrus Higher in oestrus Higher in dioestrus Up-regulated in oestrus after inoculation Up-regulated in dioestrus after inoculation
Antigen processing and presentation 73* (32) 52* (25) 15 3 5 4 219
B cell receptor signaling pathway 52* (12) 35* (12) 13 4 5 4 112
Chemokine signaling pathway 107* (5) 73* (6) 27* 13 13 10 190
Complement and coagulation cascades 32 29* (29) 19* 12 13* 12* 81
Cytosolic DNA-sensing pathway 34* (27) 24* (21) 10 0 5 0 95
Fc epsilon RI signaling pathway 48* (17) 30* (18) 13 6 6 5* 184
Fc gamma R-mediated phagocytosis 64* (11) 36* (20) 16 11 4 4 71
Hematopoietic cell lineage 54* (16) 46* (9) 16* 5 12* 10* 183
Intestinal immune network for IgA production 39 31* (39) 5 0 3 3 227
Leukocyte transendothelial migration 78* (19) 50* (16) 32* 12 12 9 118
Natural killer cell mediated cytotoxicity 100* (2) 65* (8) 28* 4 13* 9 244
NOD-like receptor signaling pathway 41* (18) 30* (14) 11 5 8* 7* 129
RIG-I-like receptor signaling pathway 35* (30) 27* (19) 10 6 6 5 114
T cell receptor signaling pathway 66 36 16 7 8 5 96
Toll-like receptor signaling pathway 65* (8) 50* (7) 19* 6 11* 9* 78
Cell adhesion molecules (CAMs) 93* (43) 75* (15) 29 13 11 8 320
Cytokine-cytokine receptor interaction 129* (4) 109* (2) 52* 14 36* 32* 273
Jak-STAT signaling pathway 80* (13) 65* (5) 33* 6 23* 21* 181
MAPK signaling pathway 120* (9) 78* (11) 48* 21 26* 18* 285
NF-kappa B signaling pathway 76* (35) 55* (23) 18 5 8 7 241
TNF signaling pathway 79* (3) 69* (3) 28* 9 19* 17* 131
  1. *Significantly enriched KEGG pathway (P-value < 0.05)
  2. aThe number of genes significantly up-regulated after bacterial inoculation in each pathway (and the rank of this pathway in comparison to all pathways found in oestrus or dioestrus sorted by P value)
  3. bThe number of genes that were found to be expressed at significantly higher levels in one cycle stage 3 h after inoculation in comparison to the other cycle stage 3 h after inoculation
  4. cThe number of genes that were found to be expressed at significantly higher levels in oestrus 3 h after inoculation in comparison to dioestrus 3 h after inoculation and were also found to be significantly up-regulated after inoculation when compared to pre-inoculation levels in oestrus or dioestrus