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Table 2 Enriched KEGG pathways in the category immune system (blue) and immune-related signal transduction molecules (green) after bacterial inoculation

From: Deep sequencing of the uterine immune response to bacteria during the equine oestrous cycle

KEGG pathway

Up-regulated genes after inoculation with E. coli a

Comparison of gene counts 3 h after inoculation with E. coli b

Genes with higher expression in oestrus at 3 h after inoculation compared to dioestrus at 3 h after inoculationc

Total number of genes in pathway

Oestrus

Dioestrus

Higher in oestrus

Higher in dioestrus

Up-regulated in oestrus after inoculation

Up-regulated in dioestrus after inoculation

Antigen processing and presentation

73* (32)

52* (25)

15

3

5

4

219

B cell receptor signaling pathway

52* (12)

35* (12)

13

4

5

4

112

Chemokine signaling pathway

107* (5)

73* (6)

27*

13

13

10

190

Complement and coagulation cascades

32

29* (29)

19*

12

13*

12*

81

Cytosolic DNA-sensing pathway

34* (27)

24* (21)

10

0

5

0

95

Fc epsilon RI signaling pathway

48* (17)

30* (18)

13

6

6

5*

184

Fc gamma R-mediated phagocytosis

64* (11)

36* (20)

16

11

4

4

71

Hematopoietic cell lineage

54* (16)

46* (9)

16*

5

12*

10*

183

Intestinal immune network for IgA production

39

31* (39)

5

0

3

3

227

Leukocyte transendothelial migration

78* (19)

50* (16)

32*

12

12

9

118

Natural killer cell mediated cytotoxicity

100* (2)

65* (8)

28*

4

13*

9

244

NOD-like receptor signaling pathway

41* (18)

30* (14)

11

5

8*

7*

129

RIG-I-like receptor signaling pathway

35* (30)

27* (19)

10

6

6

5

114

T cell receptor signaling pathway

66

36

16

7

8

5

96

Toll-like receptor signaling pathway

65* (8)

50* (7)

19*

6

11*

9*

78

Cell adhesion molecules (CAMs)

93* (43)

75* (15)

29

13

11

8

320

Cytokine-cytokine receptor interaction

129* (4)

109* (2)

52*

14

36*

32*

273

Jak-STAT signaling pathway

80* (13)

65* (5)

33*

6

23*

21*

181

MAPK signaling pathway

120* (9)

78* (11)

48*

21

26*

18*

285

NF-kappa B signaling pathway

76* (35)

55* (23)

18

5

8

7

241

TNF signaling pathway

79* (3)

69* (3)

28*

9

19*

17*

131

  1. *Significantly enriched KEGG pathway (P-value < 0.05)
  2. aThe number of genes significantly up-regulated after bacterial inoculation in each pathway (and the rank of this pathway in comparison to all pathways found in oestrus or dioestrus sorted by P value)
  3. bThe number of genes that were found to be expressed at significantly higher levels in one cycle stage 3 h after inoculation in comparison to the other cycle stage 3 h after inoculation
  4. cThe number of genes that were found to be expressed at significantly higher levels in oestrus 3 h after inoculation in comparison to dioestrus 3 h after inoculation and were also found to be significantly up-regulated after inoculation when compared to pre-inoculation levels in oestrus or dioestrus