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Fig. 5 | BMC Genomics

Fig. 5

From: Major differential gene regulation in Coxiella burnetii between in vivo and in vitro cultivation models

Fig. 5

Some metabolic pathways and pathways implicated in virulence and repair mechanisms induced in vivo compared to in vitro cultivation. The pathways were drawn according to KEGG database. Circles next to each gene display its regulation for each condition. ai represent significantly up-regulated KEGG pathways under in vivo conditions: a Cardiolipin synthesis, b Mevalonate pathway, c Tryptophan synthesis, d Biotin synthesis, e Thiamine synthesis, f Fatty acid degradation, g Base excision repair, h Nucleotide excision repair, and i LPS synthesis. Reactivity of in vivo vs cell and cell-free cultures are always the same (except cbu0608, due to induction of mevalonate pathway in cell culture similar to in vivo, relative to cell-free culture system)

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