Table 1 Significantly regulated (KEGG) Pathways in different culture models of C. burnetii

Metabolic pathways

cbu00230

 Purine metabolism

5.20E-18*

2.00E-01

5.40E-06*

1.10E-12*

cbu00010

 Glycolysis/Gluconeogenesis

1.00E-13*

3.80E-03*

1.50E-07*

1.50E-07*

cbu00190

 Oxidative phosphorylation

3.10E-10*

2.40E-01

1.90E-02*

1.30E-01

cbu00240

 Pyrimidine metabolism

5.20E-06*

9.80E-03*

1.80E-08*

5.60E-05*

cbu00564

 Glycerophospholipid metabolism

1.80E-05*

6.30E-02

6.00E-02

6.80E-02

cbu00020

 Citrate cycle (TCA cycle)

9.20E-04*

-

3.40E-02*

5.30E-02

cbu00071

 Fatty acid metabolism

3.10E-03*

-

-

-

cbu00061

 Fatty acid biosynthesis

3.20E-03*

1.40E-02*

7.40E-02

7.90E-02

Biosynthesis of secondary metabolites

cbu00900

 Terpenoid backbone biosynthesis

2.80E-05*

-

-

-

cbu00780

 Biotin metabolism

1.00E-04*

1.00E-03*

2.30E-03*

2.40E-06*

cbu00730

 Thiamine metabolism

6.10E-04*

7.90E-03*

9.80E-03*

1.30E-05*

Biosynthesis of amino acids

cbu00400

 Aromatic amino acids biosynthesis

8.40E-08*

-

-

-

cbu00250

 Alanine, aspartate and glutamate metabolism

3.40E-05*

-

2.30E-02*

1.20E-03*

cbu00260

 Glycine, serine and threonine metabolism

2.20E-04*

1.60E-04*

2.30E-06*

1.10E-04*

Virulence

cbu00540

 Lipopolysaccharide biosynthesis

5.40E-10*

2.80E-04*

3.70E-05*

1.90E-04*

cbu03070

 Bacterial secretion system

7.40E-08*

6.90E-02

-

1.30E-03*

Repair mechanisms

cbu03430

 Mismatch repair

7.90E-13*

-

3.60E-06*

1.50E-17*

cbu03410

 Base excision repair

1.00E-07*

-

3.40E-02*

2.50E-05*

cbu03420

 Nucleotide excision repair

8.00E-07*

-

-

4.50E-02*

Others

cbu00550

 Peptidoglycan biosynthesis

4.00E-13*

-

-

3.30E-03*

cbu02010

 ABC transporters

1.00E-04*

-

4.00E-02*

1.10E-03*

cbu02020

 Two-component system

3.50E-03*

-

-

-