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Fig. 9 | BMC Genomics

Fig. 9

From: Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential

Fig. 9

Co-occurrence network of resistance genes in genomes. The network was built based on the observed co-occurrence pattern of BMRGs with ARGs in 2522 completely sequenced bacterial genomes (2666 chromosomes and 1926 plasmids). For BMRGs, only a subset of resistance genes towards metals (i.e. mercury, arsenic, cadmium, copper, zinc, bismuth, antimony and silver) was used in order to simplify the network and make trends visible. The network was filtered such that only connections between BMRGs and ARGs, and between integrases/transposases and resistance genes were kept if the connected genes occurred together in at least ten genomes (i.e. strains) irrespective of their location (chromosomes and/or plasmids). For clarity and illustration purposes, the connections between BMRGs are not shown. No connections are shown between ARGs to better emphasize the co-selection potentials. The thickness of each connection (an edge) between two resistance genes (nodes) is proportional to the number of times the two resistance genes co-occurred in the same genomes. ‘ARG + BMRG’ refers to the genes that confer resistance/tolerance to both antibiotics and biocides/metals

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