Fig. 2From: Genomic mutational analysis of the impact of the classical strain improvement program on β–lactam producing Penicillium chrysogenum Mutational impact of the CSI program on secondary metabolite gene clusters of P. chrysogenum. a Mutations acquired by Wisconsin 54-1255 in period 1 of the CSI programme are colored in red. The mutagenic impact in period 2 is shown in green. Mutated PKS and NRPS domains are indicated. The grey arrows represent other genes of the putative gene clusters. Abbreviations used for PKS and NRPS domains: KS, keto-synthase; AT, acyltransferase; DH, dehydratase; MT, methyltransferase; ER, enoyl reductase; KR, ketoreductase; ACP, acyl carrier protein; TE, thioesterase; TE/Red, thioester reductase; A, adenylation; T, thiolation; C, condensation domain. b Schematic representation of the Velvet complex proteins VelA, VelB and LaeA with the mutations obtained during the CSIBack to article page