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Table 1 The top 10 most down- , and the top 10 most up- regulated (expression of) genes in AD affected CPE versus healthy CPE

From: Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer’s disease

Fold change Symbol Entrez gene name Location
−18.03 C6orf58 Chromosome 6 open reading frame 58 Cytoplasm
−8.09 BRCA2 Breast cancer 2, early onset Nucleus
−7.71 FABP4 Fatty acid binding protein 4, adipocyte Cytoplasm
−7.18 RPS4Y1 Ribosomal protein S4, Y-linked 1 Cytoplasm
−6.57 PRND Prion protein 2 (dublet) Pl. Membr.
−6.27 LRRC74B Leucine rich repeat containing 74B Other
−6.26 C10orf107 Chromosome 10 open reading frame 107 Other
−5.76 NEBL-AS1 NEBL antisense RNA 1 Other
−5.66 RBM3 RNA binding motif (RNP1, RRM) protein 3 Cytoplasm
−5.39 TXLNGY Taxilin gamma pseudogene, Y-linked Other
11.37 LSMEM1 Leucine-rich single-pass membrane protein 1 Cytoplasm
9.45 ETNPPL Ethanolamine-phosphate phospho-lyase Other
9.15 HSPA1A/HSPA1B Heat shock 70kDa protein 1A Cytoplasm
7.04 HSPA6 Heat shock 70kDa protein 6 (HSP70B’) Nucleus
6.56 LHFPL3-AS2 LHFPL3 antisense RNA 2 Other
6.24 CELSR1 Cadherin, EGF LAG seven-pass G-type receptor 1 Pl. Membr.
5.72 RCC1 Regulator of chromosome condensation 1 Cytoplasm
5.55 DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 Nucleus
5.42 SERPINC1 Serpin peptidase inhibitor, clade C (antithrombin), member 1 Extracell. Sp.
5.1 ZBTB1 Zinc finger and BTB domain containing 1 Nucleus
  1. Names of the genes are abbreviated according to Genbank. For potential relationship with AD according to the scientific literature, see description in the main text
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