Skip to main content
Fig. 4 | BMC Genomics

Fig. 4

From: Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges

Fig. 4

Transcriptome analysis reveals an enriched downregulation of miR-155 and miR-802 predicted targets. a Gene Set Enrichment Analysis of array data was performed on the set of mouse predicted targets for miR-155 (left panel) and miR-802 (right panel) in TargetScan6.2. b Analysis of gene expression explained by the number of predicted miRNA sites. Box plots represent the distribution of miRComb Pearson correlation coefficients among the targets sorted according to the predicted number of target sites (+ represent the mean of the distribution). * and *** denote p < 0.05 and p < 0.001, respectively. c Representation of the correlations between predicted target genes and miR-155 (green) and miR-802 (blue) according to its topology in mouse genome. The layer over the chromosomes represents in graphic bars the regulation of genes within subchromosomic segments of 1000 kb. Representation was performed using CIRCOS visualisation package. Represented correlations are those that presented negative coefficients for a predicted target and a p-value < 0.05 in miRComb analysis

Back to article page
\