Skip to main content

Table 2 KEGG pathways affected by the direction of cross in F1 males (p < 0.05)

From: The direction of cross affects obesity after puberty in male but not female offspring

KEGG ID Major category/Subcategory Pathway Name Proportion of genes in pathway Identified genes 1 fold-change (matBFMI vs. patBFMI) TFBS 2 Corrected P-Value for pathway ORA
04710 Organismal Systems/ Environmental adaptation Circadian rhythm 10 % Arntl (0.54) - 0.00087
Per2 (1.32) -
Per3 (1.71) -
04146 Cellular Processes/Transport and catabolism Peroxisome 5 % Abcd1 (1.22) - 0.00094
Abcd2 (1.52) -
Acsl3 (1.22) -
Crat (1.27) -
00830 Metabolism/Metabolism of cofactors and vitamins Retinol metabolism 5 % Cyp2c38 (1.61) Esrra, Esrrb 0.00113
Cyp2c39 (1.29) Esrra, Esrrb
Cyp4a10 (1.35) ERE, IR3
Cyp4a14 (1.32) -
00590 Metabolism/Lipid metabolism Arachidonic acid metabolism 4 % Cyp2c38 (1.61) Esrra, Esrrb 0.00099
Cyp2c39 (1.29) Esrra, Esrrb
Cyp4a10 (1.35) ERE, IR3
Cyp4a14 (1.32) -
00071 Metabolism/Lipid metabolism Fatty acid degradation 6 % Acsl3 (1.22) - 0.00198
Cyp4a10 (1.35) ERE, IR3
Cyp4a14 (1.32) -
00061 Metabolism/Lipid metabolism Fatty acid biosynthesis 14 % Acsl3 (1.22) - 0.00282
Fasn (1.22) ERE
03320 Organismal Systems/ Endocrine system PPAR signaling pathway 4 % Acsl3 (1.22) - 0.00617
Cyp4a10 (1.35) ERE, IR3
Cyp4a14 (1.32) -
00062 Metabolism/ Lipid metabolism Fatty acid elongation 8 % Acot4 (1.82) - 0.00627
Elovl6 (1.32) -
00140 Metabolism/Lipid metabolism Steroid hormone biosynthesis 4 % Cyp2c38 (1.61) Esrra, Esrrb 0.00636
Cyp2c39 (1.29) Esrra, Esrrb
Cyp7b1 (0.83) -
01040 Metabolism/ Lipid metabolism Biosynthesis of unsaturated fatty acids 8 % Acot4 (1.82) - 0.00635
Elovl6 (1.32) -
04270 Organismal Systems/Circulatory system Vascular smooth muscle contraction 2 % Avpr1a (0.77) - 0.01549
Cyp4a10 (1.35) ERE, IR3
Cyp4a14 (1.32) -
02010 Environmental information processing/Membrane transport ABC transporters 4 % Abcd1 (1.22) - 0.01649
Abcd2 (1.52) -
00591 Metabolism/ Lipid metabolism Linoleic acid metabolism 4 % Cyp2c38 (1.61) Esrra, Esrrb 0.01884
Cyp2c39 (1.29) Esrra, Esrrb
04640 Organismal systems/Immune system Hematopoietic cell lineage 2 % Dntt (1.24) - 0.04814
Il1r1 (0.74) -
  1. 1P-value for differential gene expression between reciprocal F1 groups of males was p < 0.05, minimum fold-change difference >20 %, The innateDB tool was used for the KEGG pathway analysis. matBFMI – BFMI mother, patBFMI – BFMI father
  2. 2Steroid hormone transcription factor binding sites. Esrra/b – estrogen related receptor a/b, ER – estrogen receptor alpha, ERE – estrogen response element, IR3 - androgen inverted repeats of hexameric half-site separated by 3 bp of spacer