Skip to main content

Table 3 Genes highly differentially expressed between the reciprocal F1 males (p < 0.05, fch > 20 %)

From: The direction of cross affects obesity after puberty in male but not female offspring

Gene Symbol1 Chr Gene description Mean RPKM2 Fch matBFMI/ t Test P-value TFBS3
patBFMI matBFMI patBFMI
Slc16a7 10 solute carrier family 16 (monocarboxylic acid transp.), 7 1.91 2.30 1.20 0.0007 Esrrb
Nlrp12 7 NLR family, pyrin domain containing 12 2.66 2.19 0.82 0.0009 ERE
Il1r1 1 interleukin 1 receptor, type I 2.16 1.60 0.74 0.0019 -
St5 7 suppression of tumorigenicity 5 1.97 1.61 0.82 0.0029 -
Hmgcr 13 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 3.01 3.98 1.32 0.0034 -
Scara5 14 scavenger receptor class A, member 5 (putative) 1.23 0.55 0.44 0.0050 -
Gpr110 17 G protein-coupled receptor 110 1.48 0.85 0.57 0.0092 -
Grem2 1 gremlin 2 homolog, cysteine knot superfamily 1.50 1.11 0.74 0.0102 -
Fasn 11 fatty acid synthase 4.47 5.41 1.21 0.0110 ERE
Selenbp2 3 selenium binding protein 2 5.72 4.76 0.83 0.0113 -
Cyp4a14 4 cytochrome P450, family 4, subfam. a, polypept. 14 3.58 4.74 1.32 0.0119 -
Cyp2c38 19 cytochrome P450, family 2, subfamily c, polypet. 38 1.46 2.33 1.60 0.0122 Esrra, Esrrb
Crat 2 carnitine acetyltransferase 1.79 2.27 1.26 0.0128 -
Coq10b 1 coenzyme Q10 homolog B (S. cerevisiae) 1.42 1.98 1.39 0.0138 -
Rai14 15 retinoic acid induced 14 1.98 1.64 0.83 0.0144 -
Mup-ps20 4 major urinary protein, pseudogene 20 1.46 0.51 0.35 0.0145 -
Arntl 7 aryl hydrocarbon receptor nuclear translocator-like 1.90 1.05 0.55 0.0151 -
Acnat2 4 acyl-coenzyme A amino acid N-acyltransferase 2 2.37 3.22 1.36 0.0155 Esrrb, IR3
Abcd2 15 ATP-binding cassette, sub-family D (ALD), 2 1.14 1.72 1.51 0.0157 -
Cyp2c39 19 cytochrome P450, family 2, subfamily c, polypept.39 2.77 3.57 1.29 0.0157 Esrra, Esrrb
Slc45a3 1 solute carrier family 45, member 3 2.15 1.72 0.80 0.0166 -
Sntg2 12 syntrophin, gamma 2 1.75 1.45 0.83 0.0187 -
Per2 1 period circadian clock 2 1.26 1.67 1.32 0.0208 -
Hcn3 3 hyperpolarization-activated, cyclic nucleotide-gated 0.95 1.51 1.60 0.0208 -
Gas6 8 growth arrest specific 6 2.26 2.73 1.21 0.0209 -
Serpina12 12 ser/cys peptidase inhibitor, member 12 2.40 1.94 0.81 0.0211 -
Elovl6 3 ELOVL family member 6, elongation of LCFA 3.20 4.17 1.30 0.0214 -
Acsl3 1 acyl-CoA synthetase long-chain family member 3 2.24 2.71 1.21 0.0215 -
Acot4 12 acyl-CoA thioesterase 4 0.93 1.66 1.79 0.0219 -
Slc20a1 2 solute carrier family 20, member 1 1.54 1.87 1.21 0.0219 -
B3galt1 2 UDP beta 1,3-galactosyltransferase, polypept.1 1.52 1.07 0.70 0.0230 -
Cyp7b1 3 cytochrome P450, family 7, subfamily b, polypept. 1 5.11 4.23 0.83 0.0257 -
Cyp4a10 4 cytochrome P450, family 4, subfamily a, polypept.10 3.78 5.02 1.33 0.0260 ERE, IR3
  1. 1Bold gene symbols indicate up regulation in F1 males of a BFMI mother. A list of all differentially expressed genes (p < 0.1) is given in Additional file 1: Table S1. Chr – chromosome, matBFMI – BFMI mother, patBFMI – BFMI father, Fch – fold-changes
  2. 2All values were log-transformed (ln)
  3. 3TFBS - Transcription factor binding sites for steroid hormones. Esrrb – estrogen related receptor b, ERE – estrogen response element, IR3 – androgen inverted repeats of hexameric half-site separated by 3 bp of spacer