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Table 3 Genes highly differentially expressed between the reciprocal F1 males (p < 0.05, fch > 20 %)

From: The direction of cross affects obesity after puberty in male but not female offspring

Gene Symbol1

Chr

Gene description

Mean RPKM2

Fch matBFMI/

t Test P-value

TFBS3

patBFMI

matBFMI

patBFMI

Slc16a7

10

solute carrier family 16 (monocarboxylic acid transp.), 7

1.91

2.30

1.20

0.0007

Esrrb

Nlrp12

7

NLR family, pyrin domain containing 12

2.66

2.19

0.82

0.0009

ERE

Il1r1

1

interleukin 1 receptor, type I

2.16

1.60

0.74

0.0019

-

St5

7

suppression of tumorigenicity 5

1.97

1.61

0.82

0.0029

-

Hmgcr

13

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

3.01

3.98

1.32

0.0034

-

Scara5

14

scavenger receptor class A, member 5 (putative)

1.23

0.55

0.44

0.0050

-

Gpr110

17

G protein-coupled receptor 110

1.48

0.85

0.57

0.0092

-

Grem2

1

gremlin 2 homolog, cysteine knot superfamily

1.50

1.11

0.74

0.0102

-

Fasn

11

fatty acid synthase

4.47

5.41

1.21

0.0110

ERE

Selenbp2

3

selenium binding protein 2

5.72

4.76

0.83

0.0113

-

Cyp4a14

4

cytochrome P450, family 4, subfam. a, polypept. 14

3.58

4.74

1.32

0.0119

-

Cyp2c38

19

cytochrome P450, family 2, subfamily c, polypet. 38

1.46

2.33

1.60

0.0122

Esrra, Esrrb

Crat

2

carnitine acetyltransferase

1.79

2.27

1.26

0.0128

-

Coq10b

1

coenzyme Q10 homolog B (S. cerevisiae)

1.42

1.98

1.39

0.0138

-

Rai14

15

retinoic acid induced 14

1.98

1.64

0.83

0.0144

-

Mup-ps20

4

major urinary protein, pseudogene 20

1.46

0.51

0.35

0.0145

-

Arntl

7

aryl hydrocarbon receptor nuclear translocator-like

1.90

1.05

0.55

0.0151

-

Acnat2

4

acyl-coenzyme A amino acid N-acyltransferase 2

2.37

3.22

1.36

0.0155

Esrrb, IR3

Abcd2

15

ATP-binding cassette, sub-family D (ALD), 2

1.14

1.72

1.51

0.0157

-

Cyp2c39

19

cytochrome P450, family 2, subfamily c, polypept.39

2.77

3.57

1.29

0.0157

Esrra, Esrrb

Slc45a3

1

solute carrier family 45, member 3

2.15

1.72

0.80

0.0166

-

Sntg2

12

syntrophin, gamma 2

1.75

1.45

0.83

0.0187

-

Per2

1

period circadian clock 2

1.26

1.67

1.32

0.0208

-

Hcn3

3

hyperpolarization-activated, cyclic nucleotide-gated

0.95

1.51

1.60

0.0208

-

Gas6

8

growth arrest specific 6

2.26

2.73

1.21

0.0209

-

Serpina12

12

ser/cys peptidase inhibitor, member 12

2.40

1.94

0.81

0.0211

-

Elovl6

3

ELOVL family member 6, elongation of LCFA

3.20

4.17

1.30

0.0214

-

Acsl3

1

acyl-CoA synthetase long-chain family member 3

2.24

2.71

1.21

0.0215

-

Acot4

12

acyl-CoA thioesterase 4

0.93

1.66

1.79

0.0219

-

Slc20a1

2

solute carrier family 20, member 1

1.54

1.87

1.21

0.0219

-

B3galt1

2

UDP beta 1,3-galactosyltransferase, polypept.1

1.52

1.07

0.70

0.0230

-

Cyp7b1

3

cytochrome P450, family 7, subfamily b, polypept. 1

5.11

4.23

0.83

0.0257

-

Cyp4a10

4

cytochrome P450, family 4, subfamily a, polypept.10

3.78

5.02

1.33

0.0260

ERE, IR3

  1. 1Bold gene symbols indicate up regulation in F1 males of a BFMI mother. A list of all differentially expressed genes (p < 0.1) is given in Additional file 1: Table S1. Chr – chromosome, matBFMI – BFMI mother, patBFMI – BFMI father, Fch – fold-changes
  2. 2All values were log-transformed (ln)
  3. 3TFBS - Transcription factor binding sites for steroid hormones. Esrrb – estrogen related receptor b, ERE – estrogen response element, IR3 – androgen inverted repeats of hexameric half-site separated by 3 bp of spacer
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BMC Genomics

ISSN: 1471-2164

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