Fig. 1

Hierarchical clustering of compounds based on their genome-wide response indices for each gene across two parasite samples. The respond index for each gene in a given perturbation is obtained as the ratio between the average transcript level of the gene following a 2 h exposure to the compound in two parasite samples and the average transcript level of the same gene across all perturbations performed in the same batch of experiments. The clustering of the compounds reveals two broad groupings (Class I- red labels and Class II- green labels) in which compounds within a group are positively correlated to each other but negatively correlated to compounds in a different group