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Fig. 3 | BMC Genomics

Fig. 3

From: An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum

Fig. 3

Principle component analysis (PCA) of transcriptional correlations between the small molecules. The first component of variation (Dim 1) splits the compounds into two clusters identical to those observed by hierarchical clustering of the compounds (Fig. 1). The PCA plot reveals complex drug relationships involving both chemical similarity and MOA. Compounds lacking a ring system (PPMP, olomucine, MMS, cerulenin, epoxomicin and z-Val-Asp) occupy the upper left quadrant of the plot in spite of their distinct MOAs, supporting a dominant influence of chemical structure on global small molecule relationships. An exception is E64 which occupies a position on the plot next to other hemoglobin digestion inhibitors (shown in red- CQ, TQ and E64). *Although the MOA of artemisinin is still unknown, the drug has been shown to require activation by heme released during hemoglobin digestion [56]

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