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Fig. 4 | BMC Genomics

Fig. 4

From: An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum

Fig. 4

Representation of small molecule transcriptional effects as binary fingerprints in which “1” encodes an enrichment of a given biological process in the top 100 induced genes while a “0” represents lack of enrichment of a given process. a Two examples of partial small molecule-GO fingerprints for chloroquine and artemisnin. b Visualization of the small molecule–GO fingerprints for the 31 compounds as a heatmap in which the enrichment of a biological process in top 100 up-regulated genes for each compound is represented in red and the lack of enrichment by green. c The small molecule-GO fingerprints can be visualized in a bipartite network composed of small molecule nodes and biological process nodes. A focused view of the up-regulated small molecule-GO relationships between rapamycin and PPMP shows that both compounds are associated with autophagy but only rapamycin is associated with protein import into nucleus and co-translational protein folding

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