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Table 1 Summary of significant features grouped in each cluster (cluster A, E, and I)a

From: Integrative phenotyping framework (iPF): integrative clustering of multiple omics data identifies novel lung disease subphenotypes

  Total Cluster A Cluster E Cluster I P-value Cluster Cluster Cluster
(n = 199) (n = 76) (n = 43) (n = 80) ANOVA A & E A & I E & I
Age, yrs 63.5 65.7 55 66.1 2.91E-07 7.68E–02 1.24E–07 5.05E–02
Gender, % female 41.2 39.5 65.1 30 7.51E–04 2.44E–02 7.23E–01 7.42E–04
Body Mass Index, BMI 28.6 28 27.5 29.8 3.29E–02 1.00E + 00 7.24E–02 1.07E–01
FEV1 % predicted 61.7 48 64.3 73.4 1.12E–13 4.37E–05 1.53E–13 3.61E–02
FVC % predicted 69.2 72.4 69.7 65.8 1.85E–02 1.00E + 00 1.79E–02 2.93E–01
FEV1/FVC ratio 0.9 0.653 0.93 1.12 3.62E–29 1.59E–09 1.49E–25 2.75E–09
DLCO 53.9 59.2 57.3 47 2.55E–03 1.00E + 00 8.14E–03 1.46E–02
Total lung capacity, mean 5.28 6.55 4.87 4.19 4.69E–19 1.16E–07 2.32E–18 4.98E–02
CT % emphysema 7.19 14.4 1.88 1.01 4.46E–13 1.73E–07 3.77E–11 3.70E–01
Lung reticular volume, ml 309 63.8 198 662 5.86E–17 2.22E–02 3.03E–16 2.32E–07
Diagnosis, % IPF 38.7 1.32 9.3 90 4.01E–33 1.16E–01 6.00E–28 6.75E–18
Diagnosis, % Emphysema 19.6 43.4 14 0 4.29E–11 3.20E–03 1.12E–10 1.99E–03
  1. aThe average values of 12 selected demographic and clinical variables in each sub–cluster groups, p–values from Kruskal–Wallis ANOVA (all three groups) and p-values from Kruskal-Wallis rank sum test (paired wise groups)