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Fig. 1 | BMC Genomics

Fig. 1

From: Variant mapping and mutation discovery in inbred mice using next-generation sequencing

Fig. 1

Breeding scheme for analysis of recessive mutations. G1 males have inherited a random set of de novo point mutations induced by ENU treatment of the G0 parent. The G1 founder will carry, on average, 3000 ENU-induced variants genome wide. They are crossed with wild-type females to generate G2 progeny. G2 females are backcrossed to the G1 males, and recessive mutant phenotypes are ascertained in their G3 offspring. In this breeding scheme the likelihood that a region unlinked to the mutation is homozygous is 0.125

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