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Fig. 4 | BMC Genomics

Fig. 4

From: Variant mapping and mutation discovery in inbred mice using next-generation sequencing

Fig. 4

Mutant phenotype analysis. Succinate dehydrogenase staining of muscle from wild-type mice (a) and line J318 (b), which shows hind limb weakness. Compared with wild-type embryos (c), Line J327 mutants show growth retardation at E18.5 (d). Compared with wild-type e18.5 embryos (e), J328 mutants have a variety of abnormalities, including caudal truncation and craniofacial defects (f). Micro-CT images of wild-type (g) and a J328 mutant (h) shows the increase in the number of costal ribs and defects in skull development. Histological sections of body skin from a wild-type (h) and a Line K416 embryo (j) reveal hyperkeratosis in the mutant. LacZ skin permeability assay will cause skin to turn blue due to a defect in skin barrier function. Shown are representative images of a wild-type (k) and a Line K416 mutant (l)

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