Skip to main content

Table 1 List of translationally regulated genes whose protein products impact directly on protein synthesis. These genes scored in both the Refseq and Ensembl databases. The gene names and functions, as extracted from the GeneCard database (, are listed

From: The effect of heterogeneous Transcription Start Sites (TSS) on the translatome: implications for the mammalian cellular phenotype

Down-regulated (MCF7/MCF10A)
EIF3E Translation initiation factor: Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.
EIF3M Translation initiation factor.
IPO5 Importin 5: Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5.
RPL7 Ribosomal protein
RPL9 Ribosomal protein
RPL22L1 The Ribosomal Protein Rpl22 Controls Ribosome Composition
RPL26 ribosomal protein
NOL10 Nucleolar Protein 11: Ribosome biogenesis factor.
NOL11 Nucleolar Protein 11: Ribosome biogenesis factor.
DDX1 Dead Box helicase implicated in mRNA processing
DHX9 RNA Helicase A, RHA: Implicated in translation of mRNAs with structured 5′TLs.
DDX58 Dead box helicase
DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase
EPRS Glutamyl-Prolyl-tRNA Synthetase
LARS leucine-tRNA synthetase
RARS Arginyl-tRNA Synthetas
HEATR1 HEAT Repeat-Containing Protein 1: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.
RPPH1 Ribonuclease P RNA Component H1: an endoribonuclease that cleaves tRNA precursor molecules to form the mature 5′ termini.
RSL24D1 Involved in the biogenesis of the 60S ribosomal subunit.
SKIV2L2 ATP-Dependent RNA Helicase: involved in the 3′-processing of the 7S pre-RNA to the mature 5.8S rRNA.
Up-regulated (MCF7/MCF10A)
ARAF v-raf murine sarcoma oncogene homolog: May also regulate the TOR signaling cascade.
EIF5AL1 Eukaryotic translation initiation factor 5A-like 1
RBM38 RNA-binding protein that specifically binds the 3′-UTR of CDKN1A transcripts. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2.