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Table 1 List of translationally regulated genes whose protein products impact directly on protein synthesis. These genes scored in both the Refseq and Ensembl databases. The gene names and functions, as extracted from the GeneCard database (http://www.genecards.org), are listed

From: The effect of heterogeneous Transcription Start Sites (TSS) on the translatome: implications for the mammalian cellular phenotype

Down-regulated (MCF7/MCF10A)

EIF3E

Translation initiation factor: Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.

EIF3M

Translation initiation factor.

IPO5

Importin 5: Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5.

RPL7

Ribosomal protein

RPL9

Ribosomal protein

RPL22L1

The Ribosomal Protein Rpl22 Controls Ribosome Composition

RPL26

ribosomal protein

NOL10

Nucleolar Protein 11: Ribosome biogenesis factor.

NOL11

Nucleolar Protein 11: Ribosome biogenesis factor.

DDX1

Dead Box helicase implicated in mRNA processing

DHX9

RNA Helicase A, RHA: Implicated in translation of mRNAs with structured 5′TLs.

DDX58

Dead box helicase

DHX15

Pre-mRNA-splicing factor ATP-dependent RNA helicase

EPRS

Glutamyl-Prolyl-tRNA Synthetase

LARS

leucine-tRNA synthetase

RARS

Arginyl-tRNA Synthetas

HEATR1

HEAT Repeat-Containing Protein 1: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.

RPPH1

Ribonuclease P RNA Component H1: an endoribonuclease that cleaves tRNA precursor molecules to form the mature 5′ termini.

RSL24D1

Involved in the biogenesis of the 60S ribosomal subunit.

SKIV2L2

ATP-Dependent RNA Helicase: involved in the 3′-processing of the 7S pre-RNA to the mature 5.8S rRNA.

Up-regulated (MCF7/MCF10A)

ARAF

v-raf murine sarcoma oncogene homolog: May also regulate the TOR signaling cascade.

EIF5AL1

Eukaryotic translation initiation factor 5A-like 1

RBM38

RNA-binding protein that specifically binds the 3′-UTR of CDKN1A transcripts. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2.