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Table 2 Enriched GO terms for differentially expressed smoking related genes in BA46

From: RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles

Gene

Gene information

GO term

APOLD1

Apolipoprotein L domain containing 1

Response to abiotic stimulus

ATP13A4

ATPase type 13A4

Transmembrane transport

ATP1A2

ATPase, Na+/K+ transporting, alpha 2 polypeptide

Behavior / response to abiotic stimulus / transmembrane transport

CIART

Circadian associated repressor of transcription

Behavior

GJA1

Gap junction protein, alpha 1, 43 kDa

Behavior / response to abiotic stimulus / transmembrane transport

GPR37

G protein-coupled receptor 37 (endothelin receptor type B-like)

Behavior

HIF3A

Hypoxia inducible factor 3, alpha subunit

Response to abiotic stimulus

IGFBP7

Insulin-like growth factor binding protein 7

Response to abiotic stimulus

MLC1

Megalencephalic leukoencephalopathy with subcortical cysts 1

Response to abiotic stimulus / transmembrane transport

PLOD2

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

Response to abiotic stimulus

PREX2

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

Behavior

PTN

Pleiotrophin

Behavior

S1PR1

Sphingosine-1-phosphate receptor 1

Behavior

SDC2

Syndecan 2

Response to abiotic stimulus

SDC4

Syndecan 4

Response to abiotic stimulus

SLC14A1

Urea transporter,Kidd blood group

Transmembrane transport

SLC1A2

Glial high affinity glutamate transporter

Behavior / response to abiotic stimulus / transmembrane transport

SLC1A3

Glial high affinity glutamate transporter

Behavior / response to abiotic stimulus / transmembrane transport

SLC4A4

Sodium bicarbonate cotransporter

Transmembrane transport

SLC5A11

Sodium/inositol cotransporter

Transmembrane transport

SLC7A11

Anionic amino acid transporter light chain, xc- system

Transmembrane transport

SLCO1C1

Solute carrier organic anion transporter

Transmembrane transport

TP53BP2

Tumor protein p53 binding protein 2

Response to abiotic stimulus

VEGFA

Vascular endothelial growth factor A

Behavior / response to abiotic stimulus

  1. Two GO terms were enriched from genes with significant (FDR ≤ 0.1) differential expression between smokers and nonsmokers in BA46