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Table 3 Patterns of leading/lagging strand mutational bias

From: The properties of spontaneous mutations in the opportunistic pathogen Pseudomonas aeruginosa

   G:C > A:T A:T > G:C
   G templating the leading stranda G templating the lagging stranda A templating the leading stranda A templating the lagging stranda
MMR-deficient MA lines Expected 173 185 166 158
Observed 279 79 97 227
Observed Leading/Lagging 3.53   0.43  
Chi-square value 67.42   30.47  
p value <0.0001 <0.0001
Wild-type MA lines Expected 12 13 4 4
Observed 15 10 6 2
Observed Leading/Lagging 1.50   3.00  
Chi-square value 0.73   1.07  
p value >0.39 >0.30
Comparative genomics of clinical isolates Expected 16364 16384 8509 8511
Observed 17794 14954 8837 8183
Observed Leading/Lagging 1.19   1.08  
Chi-square value 125.12   12.65  
p value <0.0001 <0.0004
  1. Observed values that are greater then expected are shown in bold. Data from both replichores were combined
  2. aFunctionally equivalent transition types were combined. For example, G templating the leading strand in the right replichore is functionally equivalent to C templating the lagging strand in the left replichore