TY - JOUR AU - Aulicino, Anna AU - Dinan, Adam M. AU - Miranda-CasoLuengo, Aleksandra A. AU - Browne, John A. AU - Rue-Albrecht, Kévin AU - MacHugh, David E. AU - Loftus, Brendan J. PY - 2015 DA - 2015/12/09 TI - High-throughput transcriptomics reveals common and strain-specific responses of human macrophages to infection with Mycobacterium abscessus Smooth and Rough variants JO - BMC Genomics SP - 1046 VL - 16 IS - 1 AB - Mycobacterium abscessus (MAB) is an emerging pathogen causing pulmonary infections in those with inflammatory lung disorders, such as Cystic Fibrosis (CF), and is associated with the highest fatality rate among rapidly growing mycobacteria (RGM). Phenotypically, MAB manifests as either a Smooth (MAB-S) or a Rough (MAB-R) morphotype, which differ in their levels of cell wall glycopeptidolipids (GPLs) and in their pathogenicity in vivo. As one of the primary immune cells encountered by MAB, we sought to examine the early transcriptional events within macrophages, following infection with both MAB-S or MAB-R. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-015-2246-1 DO - 10.1186/s12864-015-2246-1 ID - Aulicino2015 ER -