Fig. 1

Library clustering and overlap of DE genes. a Unsupervised hierarchical clustering of mRNA libraries based on the normalised expression levels of the 50 most variable genes. Libraries from MAB-R- and MAB-S-infected cells group separately from uninfected cells, with the 4 and 24 hpi infection libraries forming a discrete cluster from all 1 hpi libraries. b Venn diagrams illustrating the overlap of DE genes identified for mRNA and miRNA libraries at 4 and 24 hpi. The numbers of DE genes were found to increase progressively during infection in both cases. MAB-S elicited a more robust response, with MAB-R inducing comparatively fewer unique DE genes