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Table 4 GO terms showing over-representation amongst genes differentially expressed in YAC128 compared with WT striata

From: Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence

ID

Term

FDR p

Count

Global

Genes down in YAC128

   

GO:0007186

G-protein coupled receptor protein signaling pathway

2.65E-12

155

1616

GO:0007165

Signal transduction

9.18E-12

256

3253

GO:0003008

System process

1.05E-09

147

1624

GO:0007600

Sensory perception

1.45E-07

125

1364

GO:0007608

Sensory perception of smell

1.26E-06

104

1098

GO:0050801

Ion homeostasis

1.47E-04

34

239

GO:0050789

Regulation of biological process

2.26E-04

379

6038

GO:0055082

Cellular chemical homeostasis

2.35E-04

32

221

GO:0042391

Regulation of membrane potential

7.05E-04

20

105

GO:0007154

Cell communication

2.58E-02

24

218

GO:0019226

Transmission of nerve impulse

3.42E-02

10

39

Genes up in YAC128

   

GO:0019884

Antigen processing and presentation of exogenous antigen

1.74E-02

8

26

  1. The full list of differentially expressed genes between genotypes is given in Table S3 and the full pathway analysis in Table S4. Count is total number of significantly differentially expressed probesets in that GO category and Global is the total membership of that GO category.