Table 4 Top 15 discriminant genes for breeds
Gene | Description | SSC | DEG breed-specific | sPLSDA-axis | Main functions |
|---|---|---|---|---|---|
KIT | v-kit Hardy-zuckerman 4 fe line sarcoma viral oncogene homolog | 8 | DU | axis 2 (LW>DU,LR) | Endocytosis, cell growth and/or maintenance |
EMC2 | ER membrane protein complex sub unit 2 | 4 | DU | axis 2 (LW>DU,LR) | Component of the ER membrane protein complex (EMC) |
TJP2 | tight junction protein 2 (zona occludens 2) | 1 | DU | axis 3 (DU>LR) | Tight junction |
PSMB4 | proteasome (prosome, macropain)sub unit, beta type, 4 | 4 | DU | axis 2/3 (DU>LR,LW,PI) | Proteasome |
VDR | vitamin D (1,25-dihydroxyvitamin D3) receptor | 5 | DU | axis 2/3 (DU<LR, LW, PI) | Mineral absorption |
OCA2 | oculocutaneous albinism II (pink-eye dilution homolog, mouse) | 15 | DU | axis 2/3 (DU<LR, LW, PI) | Transport of tyrosine |
RAB18 | RAB18, member RAS oncogene family | 10 | LWF | axis 2 (LW<DU,LR) | Two-component signal transduction system (phosphorelay) |
PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 6 | LWF | axis 2 (LW<DU,LR) | Protein amino acid phosphorylation; signal transduction; Insulin signaling pathway, Gap |
TW3 | tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) | 6 | LWF | axis 2 (LW>DU,LR) | RNA translation, tRNA stabilization |
GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 7 | LWF | axis 2 (LW<DU,LR) | Apoptosis; cytolysis; proteolysis and peptidolysis |
NAA20 | N(alpha)-acetyltransferase 20, NatBcatalytic subunit | 17 | PI | axis 1 (PI<DU,LR,LW) | CotranslationalN(alpha)-terminal acetylation of methionine residues |
MOB3C | MOB kinase activation3C | 6 | PI | axis 1 (PI<DU,LR,LW) | Protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation |
PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 9 | PI | axis 1 (PI>DU,LR,LW) | G-protein coupled receptorprotein signaling pathway; Regulation of actin cytoskeleton |
RNGIT | RNA guanylyltransferase and 5’-phosphatase | 1 | PI | axis 1 (PI<DU,LR,LW) | mRNA capping; protein amino acid dephosphorylation |
DPHS | diphthamide biosynthesis 5 | 4 | PI | axis 1 (PI<DU,LR,LW) | Diphthamide synthesis pathway |