Table 2 Effects of the altered genes after transfection of cells with PEI and control siRNAs on vascular system in the literature

KRT5

Overexpression enhanced vascular proliferation leading to cell hyperplasia in urinary bladder

[31]

DSC2

Mutations may predict arrhythmic events and sudden cardiac death

[32]

CASP14

Deletion may be the cause of vascular neurodegenerative disorder

[33]

PKP1

Overexpression in head and neck tumor tissues

[34]

SFN

Inhibited intimal hyperplasia in rat carotid injury model

[35]

MMRN2

Overexpression impaired tumor growth through VEGF pathway interference

[36]

STAT4

Upregulated during intimal hyperplasia

[9]

ELN

Aberrations caused aortic aneurysm

[37]

CCL8

Reduced macrophage accumulation in the vascular wall and blood pressure in hypertension.

[8]

SOD2

Protected against oxidative stress and endothelial dysfunction in carotid artery

[38]

C8orf4

Used as an endothelial inflammatory marker

[10]

NR3C2

Under expression may cause angiogenesis in colorectal carcinomas [39]

[39]

Contributed to vascular remodeling and target organ damage [40]

[40]

CSF2

Stimulated arteriogenesis in pig peripheral artery disease model

[41]

AMH

Upregulation associated with varicose vein disease

[42]