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Table 2 Effects of the altered genes after transfection of cells with PEI and control siRNAs on vascular system in the literature

From: The effects of transfection reagent polyethyleneimine (PEI) and non-targeting control siRNAs on global gene expression in human aortic smooth muscle cells

Genes Effects on vascular system References
KRT5 Overexpression enhanced vascular proliferation leading to cell hyperplasia in urinary bladder [31]
DSC2 Mutations may predict arrhythmic events and sudden cardiac death [32]
CASP14 Deletion may be the cause of vascular neurodegenerative disorder [33]
PKP1 Overexpression in head and neck tumor tissues [34]
SFN Inhibited intimal hyperplasia in rat carotid injury model [35]
MMRN2 Overexpression impaired tumor growth through VEGF pathway interference [36]
STAT4 Upregulated during intimal hyperplasia [9]
ELN Aberrations caused aortic aneurysm [37]
CCL8 Reduced macrophage accumulation in the vascular wall and blood pressure in hypertension. [8]
SOD2 Protected against oxidative stress and endothelial dysfunction in carotid artery [38]
C8orf4 Used as an endothelial inflammatory marker [10]
NR3C2 Under expression may cause angiogenesis in colorectal carcinomas [39] [39]
Contributed to vascular remodeling and target organ damage [40] [40]
CSF2 Stimulated arteriogenesis in pig peripheral artery disease model [41]
AMH Upregulation associated with varicose vein disease [42]