TY - JOUR AU - Lai, Keng Po AU - Li, Jing-Woei AU - Gu, Je AU - Chan, Ting-Fung AU - Tse, William Ka Fai AU - Wong, Chris Kong Chu PY - 2015 DA - 2015/12/18 TI - Transcriptomic analysis reveals specific osmoregulatory adaptive responses in gill mitochondria-rich cells and pavement cells of the Japanese eel JO - BMC Genomics SP - 1072 VL - 16 IS - 1 AB - Homeostasis of ions and water is important for the maintenance of cellular functions. The regulation of the homeostasis is particularly important in euryhaline fish that migrate between freshwater (FW) and seawater (SW) environments. The fish gill, the major tissue that forms an interface separating the extracellular fluids and external water environment, has an effective transport system to maintain and regulate a constant body osmolality. In fish gills, the two major epithelial cells, pavement cells (PVCs) and mitochondria-rich cells (MRCs), are known to play key and complementary roles in ion transport at the interface. Discovering the robust mechanisms underlying the two cell types’ response to osmotic stress would benefit our understanding of the fundamental mechanism allowing PVCs and MRCs to handle osmotic stress. Owing to the limited genomic data available on estuarine species, existing knowledge in this area is slim. In this study, transcriptome analyses were conducted using PVCs and MRCs isolated from Japanese eels adapted to FW or SW environments to provide a genome-wide molecular study to unravel the fundamental processes at work. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-015-2271-0 DO - 10.1186/s12864-015-2271-0 ID - Lai2015 ER -