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Table 8 Sample size of the replication study needed for 6 diseases of WTCCC dataset when average power is estimated by EB based method. The Control-to-Case ratio of the replication study is set to 1. The significance levels used in the primary study and the replication study are α 1=5×10−8 and α 2=5×10−6, respectively

From: Power estimation and sample size determination for replication studies of genome-wide association studies

 

50 %

60 %

70 %

80 %

90 %

Coronary artery disease

4095

4784

5652

6885

9121

Crohn’s disease

4405

5252

6376

8092

11,552

Hypertension

5993

6992

8244

10,014

13,215

Rheumatoid arthritis

2666

3329

4147

5291

7357

Type 1 diabetes

2146

2640

3249

4094

5588

Type 2 diabetes

4027

4726

5633

6988

9721